| 2021-02-06 10:00:1006/02/2021 |   Bulldogs vs Roosters | 0 - 42 | | R1 |
| 2021-02-06 10:00:4906/02/2021 |   Dragons v Knights | 4 - 10 | | R1 |
| 2021-02-06 11:00:5706/02/2021 |   Tigers v Eels | 22 - 12 | | R1 |
| 2021-02-06 12:00:0206/02/2021 |   Raiders v Sharks | 12 - 16 | | R1 |
| 2021-02-06 12:10:3206/02/2021 |  Steelers vs BYE | 0 - 0 | | R1 |
| 2021-02-12 19:30:5912/02/2021 | Sharks v Bulldogs | 18 - 8 | | R2 |
| 2021-02-13 11:00:3913/02/2021 | Tigers vs Raiders | 16 - 10 | | R2 |
| 2021-02-13 12:30:1913/02/2021 | Steelers vs Roosters | 10 - 4 | | R2 |
| 2021-02-13 12:30:2813/02/2021 | Eels vs Knights | 0 - 24 | | R2 |
| 2021-02-13 19:35:1813/02/2021 | Dragons vs BYE | 19:35:187:35 pm | | R2 |
| 2021-02-20 10:00:3420/02/2021 | Tigers vs Bulldogs | 26 - 12 | | R3 |
| 2021-02-20 10:00:4020/02/2021 | Dragons vs Eels | 40 - 0 | | R3 |
| 2021-02-20 11:00:0320/02/2021 | Raiders vs Steelers | 16 - 28 | | R3 |
| 2021-02-20 14:00:2720/02/2021 | Roosters vs Knights | 10 - 22 | | R3 |
| 2021-02-20 14:10:2220/02/2021 | Sharks vs BYE | 0 - 0 | | R3 |
| 2021-02-27 12:00:0827/02/2021 | Eels vs Steelers | 12 - 42 | | R4 |
| 2021-02-27 13:15:2527/02/2021 | Bulldogs vs Raiders | 12 - 24 | | R4 |
| 2021-02-27 14:00:1827/02/2021 | Sharks vs Knights | 4 - 24 | | R4 |
| 2021-02-28 09:45:0828/02/2021 | Tigers vs Dragons | 20 - 12 | | R4 |
| 2021-02-28 15:40:0228/02/2021 | Roosters vs BYE | 0 - 0 | | R4 |
| 2021-03-06 10:00:2206/03/2021 | Steelers vs Dragons | 32 - 14 | | R5 |
| 2021-03-06 10:00:3606/03/2021 | Eels vs Bulldogs | 26 - 20 | | R5 |
| 2021-03-06 12:45:2906/03/2021 | Roosters vs Sharks | 14 - 8 | | R5 |
| 2021-03-06 13:00:4806/03/2021 | Raiders vs Knights | 12 - 30 | | R5 |
| 2021-03-06 13:00:5806/03/2021 | Tigers vs BYE | 0 - 0 | | R5 |
| 2021-03-13 10:00:1813/03/2021 | Steelers vs Sharks | 44 - 4 | | R6 |
| 2021-03-13 11:00:2113/03/2021 | Knights vs Tigers | 46 - 12 | | R6 |
| 2021-03-13 12:00:3913/03/2021 | Raiders vs Eels | 16 - 16 | | R6 |
| 2021-03-13 13:00:1613/03/2021 | Roosters vs Dragons | 8 - 48 | | R6 |
| 2021-03-13 13:10:1313/03/2021 | Bulldogs vs BYE | 0 - 0 | | R6 |
| 2021-03-27 10:00:5827/03/2021 | Sharks vs Tigers | 18 - 14 | | R8 |
| 2021-03-27 12:00:0727/03/2021 | Knights vs Steelers | 30 - 0 | | R8 |
| 2021-03-27 12:00:5627/03/2021 | Eels vs Roosters | 0 - 50 | | R8 |
| 2021-03-27 12:10:5527/03/2021 | Raiders vs BYE | 0 - 0 | | R8 |
| 2021-03-27 15:30:5427/03/2021 | Bulldogs vs Dragons | 4 - 8 | | R8 |
| 2021-04-02 10:00:0702/04/2021 | Dragons vs Sharks | 26 - 8 | | R9 |
| 2021-04-03 10:00:0703/04/2021 | Steelers vs Tigers | 10 - 25 | | R9 |
| 2021-04-03 11:00:4003/04/2021 | Knights vs Bulldogs | 18 - 22 | | R9 |
| 2021-04-03 11:30:1703/04/2021 | Roosters vs Raiders | 26 - 12 | | R9 |
| 2021-04-04 10:10:1904/04/2021 | Eels vs BYE | 0 - 0 | | R9 |
| 2021-04-10 10:00:1310/04/2021 | Knights vs BYE | 0 - 0 | | R7 |
| 2021-04-10 10:00:5210/04/2021 | Sharks vs Eels | 12 - 30 | | R7 |
| 2021-04-10 10:30:3810/04/2021 | Dragons vs Raiders | 26 - 26 | | R7 |
| 2021-04-10 11:30:5110/04/2021 | Bulldogs vs Steelers | 10 - 30 | | R7 |
| 2021-04-10 12:00:2310/04/2021 | Roosters vs Tigers | 30 - 10 | | R7 |
| 2021-04-17 11:00:1217/04/2021 | Tigers vs Dragons | 8 - 30 | | R10 |
| 2021-04-17 11:00:2017/04/2021 | Roosters vs Sharks | 20 - 0 | | R10 |
| 2021-04-17 11:05:0817/04/2021 | Steelers vs BYE | 0 - 0 | | R10 |
| 2021-04-17 11:05:4817/04/2021 | Knights vs BYE | 0 - 0 | | R10 |
| 2021-04-19 12:45:0919/04/2021 | Steelers vs Roosters | 4 - 22 | | R11 |
| 2021-04-24 11:00:1224/04/2021 | Knights vs Dragons | 10 - 26 | | R11 |
| 2021-05-01 11:00:3401/05/2021 | Roosters vs Dragons | 4 - 30 | | R12 |
